The mulberry leaf extract has the functions of regulating blood sugar, evacuating wind heat, clearing the lungs and moistening the dryness, and clearing the liver and clearing the eye.
The hypoglycemic effect of mulberry leaves is achieved by two ways: First, the alkaloid DNJ (1-deoxynojirimycin) inhibits the activity of disaccharide-degrading enzymes, thereby inhibiting the absorption of disaccharides by the small intestine and reducing the consumption. The high peak of post-glycemia (Kimura, 1995); the second is to promote β-cell insulin by mulberry alkaloid fagomine and mulberry leaf polysaccharide, and insulin can promote cell sugar utilization, hepatic glycogen synthesis and improve glucose metabolism, and finally Achieve the effect of lowering blood sugar.
Polyhydroxynorsamine isolated from mulberry leaves has a strong glycosidase inhibition (Asano et al., 1994); N-Me-DNJ, GAL-DNJ and fagomine can significantly lower blood glucose levels, of which GAL- DNJ and fagomine have the strongest blood sugar lowering effect.